Clinical Study Title:
Controlled nicorandil administration for myocardial protection during coronary artery bypass grafting under cardiopulmonary bypass.

Plain English Summary:

The use of nicorandil or vitamin B3 has been gaining support for its protective effects for the heart. This study examined its usefulness in delivery during a cardiopulmonary bypass surgery. A total of 70 patients undergoing surgery were enrolled. Half of the participants received nicorandil during surgery, while the other half received nothing. Those patients who received the nicorandil had better recovery and lower plasma levels. The study supported the use of nicorandil during cardiopulmonary bypass surgery, and further supports the idea that nicorandil, or vitamin B3, has a protective effect on the function of the heart.

Authors

Hayashi Y. Sawa Y. Ohtake S. Nishimura M. Ichikawa H. Matsuda H.

Institution

Department of Surgery, Osaka University Graduate School of Medicine, Suita City, Japan.

Country of Publication

United States

Source

Journal of Cardiovascular Pharmacology. 38(1):21-8, 2001 Jul.