Clinical Study Title:
Vitamin C Supplements Improve Endothelial Functioning

Plain English Summary:

There are many risk factors associated with coronary artery disease, including abnormalities in endothelium-derived nitric oxide. There has been some evidence that the use of vitamin C supplements can help to improve endothelial functioning and thus lower risk of coronary artery disease. Participants who already have coronary artery disease were given a one time dose of vitamin C, a daily supplement of vitamin C or a placebo. The function of the endothelial and brachial systems was then measured. The use of the daily vitamin C supplementation may help to maintain healthy functioning of the heart, especially for people who already have coronary artery disease.

Authors

Gokce N. Keaney JF Jr. Frei B. Holbrook M. Olesiak M. Zachariah BJ. Leeuwenburgh C. Heinecke JW. Vita JA.

Institution

Evans Memorial Department of Medicine, Cardiology Section, and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA.

Country of Publication

United States

Source

Circulation. 99(25):3234-40, 1999 Jun 29.